Police and emergency services responded to a two vehicle crash on Mamre Road, near Abbotts road at about 1:30pm on Tuesday.
The crash involved a passenger van carrying nine people and a commercial van with two people.
Three children - two boys aged nine months and three years, and a two-year-old girl – were taken to Westmead Hospital but the girl died after arriving at hospital.
A 59-year-old man with critical injuries and a 23-year-old woman with leg injuries were taken to Liverpool Hospital, as were a 20-year-old woman, a 16-year-old boy and two girls aged 16 and 10 who suffered minor injuries.
The two occupants of the commercial van were not injured.
Officers from the Metropolitan Crash Investigation Unit examined the scene and are continuing to investigate all circumstances surrounding the crash.
Anyone with information relating to the crash is urged to call Crime Stoppers on 1800 333 000.
This article originally appeared on New Idea.